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Author:Biniyam Girma , Getnet Yimer , Eyasu Makonnen
Data Source:[J].BMC Complementary and Alternative Medicine(IF 2.082), 2015, Vol.15 (1)Springer
Abstract:Abstract(#br) Background(#br)Cancer as a multistage process can be reversed or blocked by using chemopreventive agents. Colon cancer chemoprevention has been widely investigated using cyclooxygenase inhibitors and many other chemicals of synthetic or natural origin. This par...
Author:Eyasu Makonnen , Michiaki Kubo
Data Source:[J].BMC Genomics(IF 4.397), 2016, Vol.17 (1)Springer
Abstract:Abstract(#br) Background(#br)Drug-induced liver injury (DILI) is a well-recognized adverse event of anti tuberculosis drugs (ATD) possibly associated with genetic variations. The objective of this study was to perform genome-wide association study (GWAS) to identify genetic ...
Author:Eyasu Makonnen , Yelamtsehay Mekonnen ...
Data Source:[J].BMC Complementary and Alternative Medicine(IF 2.082), 2015, Vol.15 (1)Springer
Abstract:Abstract(#br) Background(#br) Moringa stenopetala has been used in traditional health systems to treat diabetes mellitus. The aim of this study was to investigate the antidiabetic activity of aqueous ethanol and n-butanol fraction of Moringa stenopetala leaves in streptozoto...
Author:Eyasu Makonnen , Leif Bertilsson
Data Source:[J].European Journal of Clinical Pharmacology(IF 2.741), 2018, Vol.74 (7), pp.903-911Springer
Abstract:Abstract(#br) Background and objectives(#br)N-acetyltransferase 2 (NAT2) metabolize several drugs including isoniazid. We investigated the effect of genotype, geographical difference, and smoking habit on NAT2 phenotype in Ethiopians.(#br) Methods(#br)Genotyping for NAT2 191G > A...
Author:Eyasu Makonnen , Getachew Aderaye ...
Data Source:[J].Liver International(IF 3.87), 2017, Vol.37 (1), pp.132-140Wiley
Abstract:Abstract(#br)Background & Aims(#br)The occurrence of drug‐induced liver injury ( DILI ) is a major issue in all phases of drug development. To identify novel biomarker candidates associated with DILI , we utilised an affinity proteomics strategy, where antibody suspension be...
Author:Eyasu Makonnen , Getachew Aderaye ...
Data Source:[J].Liver International(IF 3.87), 2014, Vol.34 (3), pp.367-378Wiley
Abstract:Abstract(#br)Background & Aims(#br)There is a demand for more sensitive, specific and predictive biomarkers for drug‐induced liver injury ( DILI ) than the gold standard used today, alanine aminotransferase ( ALT ). The aim of this study was to qualify novel DILI biomarkers ...
Author:... Asfaw Debella , Wondwossen Ergete , Eyasu Makonnen
Data Source:[J].BMC Research Notes, 2016, Vol.9 (1)Springer
Abstract:Abstract(#br) Background(#br)The butanol fractionated root extract of Asparagus africanus Lam., a traditional herb widely used to treat various ailments were analyzed for the presence of potential toxicity after single (acute) and repeated (subchronic) dose oral administrati...
Author:Eyasu Makonnen , Leif Bertilsson
Data Source:[J].European Journal of Clinical Pharmacology(IF 2.741), 2003, Vol.59 (7), pp.533-536Springer
Abstract:Abstract(#br) Objectives(#br)To investigate xanthine oxidase (XO) polymorphism in Ethiopians and influence of environmental factors, smoking habit and gender-related differences on enzyme activity among Ethiopians living in Ethiopia or Sweden.(#br) Methods(#br)One hundred he...
Author:Eyasu Makonnen , Getnet Yimer ...
Data Source:[J].Medicine(IF 4.233), 2016, Vol.95 (34), pp.e4631-e4631Wolters Kluwer
Abstract:ABSTRACT: Initiation of efavirenz-based combination antiretroviral therapy (cART) is associated with Vitamin D deficiency, but the risk factors including efavirenz pharmacokinetics for cART-induced severe vitamin D deficiency (SVDD) and the impact of anti-tuberculosis (TB) c...

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