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Author:... Deshmukh Abhijeet , Prasad Neha , Jang Yoon-Young
Data Source:[J].International journal of biological sciences(IF 3.168), 2016, Vol.12 (9), pp.1052-62PubMed
Abstract:Alcohol consumption has long been a global problem affecting human health, and has been found to influence both fetal and adult liver functions. However, how alcohol affects human liver development and liver progenitor cells remains largely unknown. Here, we used human induced pl...
Author:Jang Yoon-Young , Cai Liuhong , Ye Zhaohui
Data Source:[J].Discovery medicine, 2016, Vol.21 (113), pp.57-64PubMed
Abstract:Genome editing is the process in which DNA sequences at precise genomic locations are modified. In the past three decades, genome editing by homologous recombination has been successfully performed in mouse for generating genetic models. The low efficiency of this process in huma...
Author:Jang Yoon-Young , Ye Zhaohui
Data Source:[J].Human genetics, 2016, Vol.135 (9), pp.1041-58PubMed
Abstract:The discovery that mature cells can be reprogrammed to become pluripotent and the development of engineered endonucleases for enhancing genome editing are two of the most exciting and impactful technology advances in modern medicine and science. Human pluripotent stem cells have ...
Author:... Prasad Neha , Tian Lipeng , Jang Yoon-Young
Data Source:[J].Methods in molecular biology (Clifton, N.J.), 2016, Vol.1357, pp.383-94PubMed
Abstract:The advent of induced pluripotent stem cell (iPSC) technology has enabled the modeling of an array of specific human disease phenotypes, aiding in the increasingly important and indispensable understanding of disease progression and pathogenesis. Pluripotent stem cell-derived hep...
Author:Tian Lipeng , Prasad Neha , Jang Yoon-Young
Data Source:[J].Methods in molecular biology (Clifton, N.J.), 2016, Vol.1353, pp.271-83PubMed
Abstract:Alcohol consumption has long been associated with a majority of liver diseases and has been found to influence both fetal and adult liver functions. In spite of being one of the major causes of morbidity and mortality in the world, currently, there are no effective strategies tha...
Author:Jang Yoon-Young , Gurakar Ahmet
Data Source:[J].Journal of clinical and translational hepatology, 2016, Vol.4 (2), pp.113-22PubMed
Abstract:Alcohol is one of the most common etiologies of liver disease, and alcoholic liver disease overall is the second most common indication for liver transplantation in the United States. It encompasses a spectrum of disease, including fatty liver disease, alcoholic hepatitis (A...
Author:... Deshmukh Abhijeet , Ye Zhaohui , Jang Yoon-Young
Data Source:[J].Stem cell reviews, 2016, Vol.12 (4), pp.500-8PubMed
Abstract:While in vitro liver tissue engineering has been increasingly studied during the last several years, presently engineered liver tissues lack the bile duct system. The lack of bile drainage not only hinders essential digestive functions of the liver, but also leads to accumulation...
Author:... Tian Lipeng , Deshmukh Abhijeet , Jang Yoon-Young
Data Source:[J].Experimental biology and medicine (Maywood, N.J.), 2016, Vol.241 (15), pp.1653-62PubMed
Abstract:Due to the limitations of research using human embryos and the lack of a biological model of human liver development, the roles of the various markers associated with liver stem or progenitor cell potential in humans are largely speculative, and based on studies utilizing animal ...
Author:Jang Yoon-Young , Thomas David L
Data Source:[J].Antiviral therapy, 2015, Vol.20 (8), pp.805-14PubMed
Abstract:Lambda interferons (IFNLs) have potent antiviral activity against HCV, and polymorphisms within the IFNL gene cluster near the IFNL3 gene strongly predict spontaneous- and treatment-related HCV infection outcomes. The mechanism(s) linking IFNL polymorphisms and HCV control is cur...
Author:Jang Yoon-Young , Cheng Linzhao
Data Source:[J].Molecular therapy : the journal of the American Society of Gene Therapy, 2015, Vol.23 (3), pp.570-7PubMed
Abstract:Efficient and precise genome editing is crucial for realizing the full research and therapeutic potential of human induced pluripotent stem cells (iPSCs). Engineered nucleases including CRISPR/Cas9 and transcription activator like effector nucleases (TALENs) provide powerful...

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