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Author:... Deshmukh Abhijeet , Prasad Neha , Jang Yoon-Young
Data Source:[J].International journal of biological sciences(IF 3.168), 2016, Vol.12 (9), pp.1052-62PubMed
Abstract:Alcohol consumption has long been a global problem affecting human health, and has been found to influence both fetal and adult liver functions. However, how alcohol affects human liver development and liver progenitor cells remains largely unknown. Here, we used human induced pl...
Author:... Sharkis Saul , Ye Zhaohui , Jang Yoon-Young
Data Source:[J].Stem cells (Dayton, Ohio), 2018PubMed
Abstract:Directed differentiation of human induced pluripotent stem cells (iPSCs) toward hepatobiliary lineages has been increasingly used as models of human liver development/diseases. As protein kinases are important components of signaling pathways regulating cell fate changes, we...
Author:Jang Yoon-Young , Cai Liuhong , Ye Zhaohui
Data Source:[J].Discovery medicine, 2016, Vol.21 (113), pp.57-64PubMed
Abstract:Genome editing is the process in which DNA sequences at precise genomic locations are modified. In the past three decades, genome editing by homologous recombination has been successfully performed in mouse for generating genetic models. The low efficiency of this process in huma...
Author:Jang Yoon-Young , Ye Zhaohui
Data Source:[J].Human genetics, 2016, Vol.135 (9), pp.1041-58PubMed
Abstract:The discovery that mature cells can be reprogrammed to become pluripotent and the development of engineered endonucleases for enhancing genome editing are two of the most exciting and impactful technology advances in modern medicine and science. Human pluripotent stem cells have ...
Author:... Anders Robert , Schwarz Kathleen B , Jang Yoon-Young
Data Source:[J].Journal of pediatric gastroenterology and nutrition, 2019, Vol.68 (1), pp.56-63PubMed
Abstract:Biliary atresia (BA) is the most common cause of pediatric end-stage liver disease and the etiology is poorly understood. There is no effective therapy for BA partly due to lack of human BA models. Towards developing in vitro human models of BA, disease-specific induced pluripote...
Author:... Tian Lipeng , Ye Zhaohui , Jang Yoon-Young
Data Source:[J].Experimental biology and medicine (Maywood, N.J.), 2019, pp.1535370219834895PubMed
Abstract:IMPACT STATEMENT(#br)In this review, we address the potential of human-induced pluripotent stem cell-based hepatobiliary differentiation technology as a means to study human liver development and cell fate determination, and to model liver diseases in an effort to develop a new h...
Author:Jang Yoon-Young , Jeong Ji-Eun ...
Data Source:[J].Annals of pediatric endocrinology & metabolism, 2019, Vol.24 (2), pp.137-141PubMed
Abstract:Vitamin D hydroxylation-deficient rickets type 1A (VDDR1A, OMIM 264700) is a rare autosomal recessive inherited disorder. Pathogenic variants in the CYP27B1 gene lead to loss of 1α-hydroxylase activity. We report the case of a 22-month-old toddler who presented with growth r...
Author:... Prasad Neha , Tian Lipeng , Jang Yoon-Young
Data Source:[J].Methods in molecular biology (Clifton, N.J.), 2016, Vol.1357, pp.383-94PubMed
Abstract:The advent of induced pluripotent stem cell (iPSC) technology has enabled the modeling of an array of specific human disease phenotypes, aiding in the increasingly important and indispensable understanding of disease progression and pathogenesis. Pluripotent stem cell-derived hep...
Author:Tian Lipeng , Prasad Neha , Jang Yoon-Young
Data Source:[J].Methods in molecular biology (Clifton, N.J.), 2016, Vol.1353, pp.271-83PubMed
Abstract:Alcohol consumption has long been associated with a majority of liver diseases and has been found to influence both fetal and adult liver functions. In spite of being one of the major causes of morbidity and mortality in the world, currently, there are no effective strategies tha...
Author:Jang Yoon-Young , Gurakar Ahmet
Data Source:[J].Journal of clinical and translational hepatology, 2016, Vol.4 (2), pp.113-22PubMed
Abstract:Alcohol is one of the most common etiologies of liver disease, and alcoholic liver disease overall is the second most common indication for liver transplantation in the United States. It encompasses a spectrum of disease, including fatty liver disease, alcoholic hepatitis (A...

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