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Author:... Deshmukh Abhijeet , Prasad Neha , Jang Yoon-Young
Data Source:[J].International journal of biological sciences(IF 3.168), 2016, Vol.12 (9), pp.1052-62PubMed
Abstract:Alcohol consumption has long been a global problem affecting human health, and has been found to influence both fetal and adult liver functions. However, how alcohol affects human liver development and liver progenitor cells remains largely unknown. Here, we used human induced pl...
Author:Jang Yoon-Young , Ye Zhaohui
Data Source:[J].Human genetics, 2016, Vol.135 (9), pp.1041-58PubMed
Abstract:The discovery that mature cells can be reprogrammed to become pluripotent and the development of engineered endonucleases for enhancing genome editing are two of the most exciting and impactful technology advances in modern medicine and science. Human pluripotent stem cells have ...
Author:Jang Yoon-Young , Gurakar Ahmet
Data Source:[J].Journal of clinical and translational hepatology, 2016, Vol.4 (2), pp.113-22PubMed
Abstract:Alcohol is one of the most common etiologies of liver disease, and alcoholic liver disease overall is the second most common indication for liver transplantation in the United States. It encompasses a spectrum of disease, including fatty liver disease, alcoholic hepatitis (A...
Author:... Deshmukh Abhijeet , Ye Zhaohui , Jang Yoon-Young
Data Source:[J].Stem cell reviews, 2016, Vol.12 (4), pp.500-8PubMed
Abstract:While in vitro liver tissue engineering has been increasingly studied during the last several years, presently engineered liver tissues lack the bile duct system. The lack of bile drainage not only hinders essential digestive functions of the liver, but also leads to accumulation...
Author:... Tian Lipeng , Deshmukh Abhijeet , Jang Yoon-Young
Data Source:[J].Experimental biology and medicine (Maywood, N.J.), 2016, Vol.241 (15), pp.1653-62PubMed
Abstract:Due to the limitations of research using human embryos and the lack of a biological model of human liver development, the roles of the various markers associated with liver stem or progenitor cell potential in humans are largely speculative, and based on studies utilizing animal ...
Author:... Schwarz Kathleen B , Ye Zhaohui , Jang Yoon-Young
Data Source:[J].Stem cell research, 2017, Vol.24, pp.25-28PubMed
Abstract:Biliary atresia (BA) is a common cause of pediatric end-stage liver disease. While its etiology is not yet clear, evidence has suggested that BA results from interactions between genetic susceptibility and environmental factors. Disease relevant human cellular models of BA will f...
Author:Jang Yoon-Young , Sharkis Saul J
Data Source:[J].Cell Cycle, 2004, Vol.3 (8), pp.980-2PubMed
Abstract:Both stem cell plasticity and cell fusion have been implicated as physiological responses to tissue injury. It remains the ultimate goal for the future to understand the regulatory control of each during regeneration. In our recent paper by Jang et al. we demonstrate the repair o...
Author:Jang Yoon-Young , Ye Zhaohui , Cheng Linzhao
Data Source:[J].Molecular Imaging, 2011, Vol.10 (2), pp.111-22PubMed
Abstract:During the last decade, there has been enormous progress in understanding both multipotent stem cells such as hematopoietic stem cells and pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells. However, it has been challenging to study development...
Author:Jang Yoon-Young , Kim Chang-Yoon ...
Data Source:[J].Journal of Preventive Medicine and Public Health, 2008, Vol.41 (2), pp.128-34PubMed
Abstract:This study was conducted to determine the reference interval of serum thyroid hormones (TSH, FT3, FT4) in healthy Korean adults.;;Health examination data from 1,591 healthy Korean adults who visited an university hospital were analyzed. Patients with specific health conditions ca...
Author:Jang Yoon-Young , Sharkis Saul J
Data Source:[J].Blood(IF 9.06), 2007, Vol.110 (8), pp.3056-63PubMed
Abstract:A low-oxygenic niche in bone marrow limits reactive oxygen species (ROS) production, thus providing long-term protection for hematopoietic stem cells (HSCs) from ROS stress. Although many approaches have been used to enrich HSCs, none has been designed to isolate primitive HSCs l...

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