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Author:... Paul K.S. Lam , Jinping Cheng , Leo L. Chan
Data Source:[J].Journal of Hazardous Materials(IF 3.925), 2017, Vol.321, pp.782-790Elsevier
Abstract:Abstract(#br)Ciguatoxins (CTXs) are natural biotoxins produced by benthic dinoflagellates of the genus Gambierdiscus , which are bioaccumulated and biotransformed along food chains in coral ecosystems. They are neurotoxins that activate voltage-gated sodium channels and disrupt i...
Author:Leo L. Chan , Alisha R. Wilkinson ...
Data Source:[J].Journal of Fluorescence(IF 1.789), 2012, Vol.22 (5), pp.1301-1311Springer
Abstract:Abstract(#br)The ability to accurately measure cell viability is important for any cell-based research. Traditionally, viability measurements have been performed using trypan blue exclusion method on hemacytometer, which allowed researchers to visually distinguish viable from non...
Author:Leo L. Chan , James C.W. Lam
Data Source:[J].Environment International(IF 6.248), 2014, Vol.66, pp.65-70Elsevier
Abstract:Abstract(#br)The present study investigated the composition profiles and levels of polybrominated diphenyl ethers (PBDEs) and five PBDE alternatives in the blubber of two species of marine mammals, Indo-Pacific humpback dolphins ( Sousa chinensis ) and finless porpoises ( Neophoc...
Author:Ian D. Block , Leo L. Chan , Brian T. Cunningham
Data Source:[J].Microelectronic Engineering(IF 1.224), 2006, Vol.84 (4), pp.603-608Elsevier
Abstract:Abstract(#br)We demonstrate a replica-molding method for submicron patterning of a low-index sol–gel nanoporous glass for the purpose of fabricating large-area (∼80 cm 2 ) label-free photonic crystal optical biosensors. Scanning electron micrographs show the sol–gel exh...
Author:Leo L. Chan , Benjamin Paradis ...
Data Source:[J].Human Immunology(IF 2.298), 2015, Vol.76 (4), pp.211-211Elsevier
Abstract:Aim(#br)There have been no major changes in reagent or instrumentation in the flow cytometry crossmatch (FC-XM) since its description in 1983. The cost of the FC instrumentations, calibrations and maintenance is a restraint for many histocompatibility labs. In this study we ...
Author:Leo L. Chan , Saujanya L. Gosangari ...
Data Source:[J].Apoptosis(IF 3.949), 2007, Vol.12 (6), pp.1061-1068Springer
Abstract:Abstract(#br)A label-free method for detecting the attachment of human cancer cells to a biosensor surface for rapid screening for biological activity is described, in which attachment of a cell results in highly localized increase of the resonant reflected wavelength of a photon...
Author:Leo L. Chan , Xuemei Zhong ...
Data Source:[J].Journal of Immunological Methods(IF 2.225), 2012, Vol.377 (1-2), pp.8-14Elsevier
Abstract:Abstract(#br)Cell proliferation is an important assay for pharmaceutical and biomedical research to test the effects of a variety of treatments on cultured primary cells or cell lines. For immunological studies, the ability to perform rapid cell proliferation analysis allows...
Author:Leo L. Chan , Alexandria Kury ...
Data Source:[J].Journal of Industrial Microbiology & Biotechnology(IF 2.321), 2012, Vol.39 (11), pp.1615-1623Springer
Abstract:Abstract(#br)The studying and monitoring of physiological and metabolic changes in Saccharomyces cerevisiae ( S. cerevisiae ) has been a key research area for the brewing, baking, and biofuels industries, which rely on these economically important yeasts to produce their products...
Author:... James C. W. Lam , Leo L. Chan , Paul K. S. Lam
Data Source:[J].Analytical and Bioanalytical Chemistry(IF 3.659), 2013, Vol.405 (10), pp.3331-3340Springer
Abstract:Abstract(#br)Ciguatera fish poisoning (CFP) is a food intoxication caused by exposure to ciguatoxins (CTXs) in coral reef fish. Rapid analytical methods have been developed recently to quantify Pacific-CTX-1 (P-CTX-1) in fish muscle, but it is destructive and can cause harm ...

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