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Author:Mark A. Smith , Laura Rabinovich-Guilatt ...
Data Source:[J].Clinical Pharmacokinetics(IF 6.109), 2017, Vol.56 (10), pp.1207-1217Springer
Abstract:Loxapine for inhalation is a drug-device combination product approved in adults for the acute treatment of agitation associated with schizophrenia or bipolar I disorder. The primary objective of this study was to develop a clinical trial protocol to support a phase I pharmacokine...
Author:Jin-Yue Sun , Xu Guo , Mark A. Smith
Data Source:[J].Journal of the American Oil Chemists' Society(IF 1.592), 2017, Vol.94 (5), pp.655-660Springer
Abstract:Atractylodes rhizome is widely used in traditional Chinese herbal medicine. Although the chemical composition of the root has been studied in detail, the oil content and fatty acid composition of the seeds of Atractylodes species have not been reported. Fatty acyl compositio...
Author:... Jean Abel , Andrea M. Robinson , Mark A. Smith
Data Source:[J].Current Addiction Reports, 2017, Vol.4 (4), pp.467-481Springer
Abstract:Exercise is a promising treatment for substance use disorder that may reduce withdrawal symptoms and prevent relapse. In this review, we discuss recent evidence from clinical and preclinical studies for its efficacy, from a behavioral to a molecular level, in order to understand ...
Author:... Andrea M. Robinson , Jean Abel , Mark A. Smith
Data Source:[J].Current Addiction Reports, 2017, Vol.4 (4), pp.455-466Springer
Abstract:This report provides an update on clinical and preclinical findings for the efficacy of exercise to prevent substance use disorder with a focus on recent evidence for sex differences and neurobiological mechanisms.
Author:... Steven F. Smith , Mark A. Smith , Sanjeeva Mohanam
Data Source:[J].Journal of Pharmacological Sciences(IF 2.15), 2019, Vol.103 (2), pp.247-251DOAJ
Abstract:In this study, we evaluated the antiproliferative and proapoptotic effects of the isothiocyanate iberin, a bioactive agent in Brassicaceae species, in human glioblastoma cells. The human glioblastoma cell cultures were treated with different concentrations of iberin and tested fo...
Author:Mark A. Smith , Elizabeth G. Pitts
Data Source:[J].Pharmacological Reports(IF 1.965), 2012, Vol.64 (4), pp.960-964Elsevier
Abstract:Abstract(#br)Background(#br)The purpose of this study was to examine the effects of voluntary wheel running on the positive reinforcing effects of heroin in rats with an established history of drug self-administration.(#br)Methods(#br)Rats were assigned to sedentary (no wheel) an...
Author:... Hyoung-Gon Lee , Mark A. Smith , George Perry
Data Source:[J].International Journal of Molecular Sciences(IF 2.464), 2009, Vol.10 (3), pp.1386DOAJ
Abstract:Alzheimer’s disease (AD) is characterized clinically by dementia and pathologically by two hallmark lesions, senile plaques and neurofibrillary tangles. About a quarter century ago these hallmark lesions were purified and their protein constituents identified, precipitating ...
Author:... Steven F. Smith , Mark A. Smith , Sanjeeva Mohanam
Data Source:[J].Journal of Pharmacological Sciences(IF 2.15), 2007, Vol.103 (2), pp.247-251Elsevier
Abstract:Abstract(#br)In this study, we evaluated the antiproliferative and proapoptotic effects of the isothiocyanate iberin, a bioactive agent in Brassicaceae species, in human glioblastoma cells. The human glioblastoma cell cultures were treated with different concentrations of iberin ...

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