AllJournalThesisConferenceNewspaperPatentStandardYear BookBook|ResearcherProject
all languages  Chinese Only  Other Languages
Author:Scott Melanie J , Li Yuehua ...
Data Source:[J].Cell death & disease(IF 6.044), 2018, Vol.9 (3), pp.369PubMed
Abstract:Group 2 innate lymphoid cells (ILC2) are one of three subgroups of innate lymphoid cells (ILC1, ILC2, and ILC3), and the major ILC population detected in the lungs. The function of ILC2 in the regulation of lung inflammation remains unclear. In the current study, we explored an i...
Author:Scott Melanie J , Li Yuehua ...
Data Source:[J].Cell death & disease(IF 6.044), 2017, Vol.8 (5), pp.e2775PubMed
Abstract:Trauma is a major cause of systemic inflammatory response syndrome and multiple organ dysfunction syndrome. Macrophages (Mφ) direct trauma-induced inflammation, and Mφ death critically influences the progression of the inflammatory response. In the current study, we explored...
Author:... Zhang Liyong , Scott Melanie J , Billiar Timothy R
Data Source:[J].Science signaling(IF 7.648), 2015, Vol.8 (361), pp.ra11PubMed
Abstract:Proteolytic cleavage of the tumor necrosis factor (TNF) receptor (TNFR) from the cell surface contributes to anti-inflammatory responses and may be beneficial in reducing the excessive inflammation associated with multiple organ failure and mortality during sepsis. Using a clinic...
Author:Scott Melanie J , Vodovotz Yoram
Data Source:[J].Frontiers in immunology, 2017, Vol.8, pp.1672PubMed
Abstract:Trauma combined with hemorrhagic shock (HS/T) leads to systemic inflammation, which results in organ injury. Toll-like Receptor 4 (TLR4)-signaling activation contributes to the initiation of inflammatory pathways following HS/T but its cell-specific roles in this setting are...
Author:... Loughran Patricia , Scott Melanie J , Billiar Timothy R
Data Source:[J].Molecular medicine (Cambridge, Mass.), 2013, Vol.19, pp.88-98PubMed
Abstract:High mobility group box 1 (HMGB1) is a DNA-binding protein that possesses cytokinelike, proinflammatory properties when released extracellularly in the C23-C45 disulfide form. HMGB1 also plays a key role as a mediator of acute and chronic inflammation in models of sterile in...
Author:... Loughran Patricia , Billiar Timothy R , Scott Melanie J
Data Source:[J].BioMed research international, 2014, Vol.2014, pp.267350PubMed
Abstract:Impairment of autophagy has been associated with liver injury. TLR4-stimulation by LPS upregulates autophagy in hepatocytes, although the signaling pathways involved remain elusive. The objective of this study was to determine the signaling pathway leading to LPS-stimulated ...
Author:... Fan Jie , Billiar Timothy R , Scott Melanie J
Data Source:[J].Molecular medicine (Cambridge, Mass.), 2017, Vol.23PubMed
Abstract:Inflammation plays a significant role in protecting hosts against pathogens. Inflammation induced by non-infectious, endogenous agents can be detrimental, and if excessive can result in organ and tissue damage. The inflammasome is a major innate immune pathway that can be ac...
Author:Scott Melanie J , Pape Hans-Christoph
Data Source:[J].Mediators of inflammation, 2015, Vol.2015, pp.458626PubMed
Abstract:Although tissue-derived high mobility group box 1 (HMGB1) is involved in many aspects of inflammation and tissue injury after trauma, its role in trauma-induced immune suppression remains elusive. Using an established mouse model of peripheral tissue trauma, which includes soft t...
Author:Scott Melanie J , Neal Matthew D
Data Source:[J].Blood advances, 2018, Vol.2 (6), pp.638-648PubMed
Abstract:Thrombocytopenia impairs host defense and hemostasis in sepsis. However, the mechanisms of how platelets regulate host defense are not fully understood. High-mobility group box 1 (HMGB1), a danger-associated molecular pattern protein, is released during infection and contributes ...

Being retrieved, please wait for a moment...

International Cooperation:cnki.scholar@cnki.net, +86-10-82896619   Feedback:scholar@cnki.net

×