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Author:Scott Melanie J , Li Yuehua ...
Data Source:[J].Cell death & disease(IF 6.044), 2018, Vol.9 (3), pp.369PubMed
Abstract:Group 2 innate lymphoid cells (ILC2) are one of three subgroups of innate lymphoid cells (ILC1, ILC2, and ILC3), and the major ILC population detected in the lungs. The function of ILC2 in the regulation of lung inflammation remains unclear. In the current study, we explored an i...
Author:Scott Melanie J , Li Yuehua ...
Data Source:[J].Cell death & disease(IF 6.044), 2017, Vol.8 (5), pp.e2775PubMed
Abstract:Trauma is a major cause of systemic inflammatory response syndrome and multiple organ dysfunction syndrome. Macrophages (Mφ) direct trauma-induced inflammation, and Mφ death critically influences the progression of the inflammatory response. In the current study, we explored...
Author:... Fan Jie , Billiar Timothy R , Scott Melanie J
Data Source:[J].Molecular medicine (Cambridge, Mass.), 2017, Vol.23PubMed
Abstract:Inflammation plays a significant role in protecting hosts against pathogens. Inflammation induced by non-infectious, endogenous agents can be detrimental, and if excessive can result in organ and tissue damage. The inflammasome is a major innate immune pathway that can be ac...
Author:Scott Melanie J , Vodovotz Yoram
Data Source:[J].Frontiers in immunology, 2017, Vol.8, pp.1672PubMed
Abstract:Trauma combined with hemorrhagic shock (HS/T) leads to systemic inflammation, which results in organ injury. Toll-like Receptor 4 (TLR4)-signaling activation contributes to the initiation of inflammatory pathways following HS/T but its cell-specific roles in this setting are...
Author:... Wang Qingde , Scott Melanie J , Billiar Timothy R
Data Source:[J].Journal of clinical and translational hepatology, 2016, Vol.4 (2), pp.151-7PubMed
Abstract:Viral infection in the liver, including hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, is a major health problem worldwide, especially in developing countries. The infection triggers a pro-inflammatory response in patients that is crucial for host defense. Recent ...
Author:Scott Melanie J , Huang Feizhou
Data Source:[J].American journal of physiology. Gastrointestinal and liver physiology, 2018PubMed
Abstract:Liver ischemia/reperfusion (I/R) injury occurs through induction of oxidative stress and release of damage-associated molecular patterns (DAMPs), including cytosolic DNA released from dysfunctional mitochondria or from the nucleus. Cyclic guanosine monophosphate-adenosine monopho...
Author:Scott Melanie J , Li Yuehua ...
Data Source:[J].Journal of leukocyte biology, 2018, Vol.103 (2), pp.175-183PubMed
Abstract:Hemorrhagic shock (HS) renders patients susceptible to development of systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) through mechanisms that are, as yet, unclear. Cell necroptosis, a form of regulated inflammatory cell death, is...
Author:Scott Melanie J , Neal Matthew D
Data Source:[J].Blood advances, 2018, Vol.2 (6), pp.638-648PubMed
Abstract:Thrombocytopenia impairs host defense and hemostasis in sepsis. However, the mechanisms of how platelets regulate host defense are not fully understood. High-mobility group box 1 (HMGB1), a danger-associated molecular pattern protein, is released during infection and contributes ...

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