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Author:Guan Jiang , Rong-Hua Li , Chao Sun ...
Data Source:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (12)
Abstract:BACKGROUND: Malignant melanoma is the most aggressive and deadly form of skin cancer. Dacarbazine (DTIC) has been the approved first-line treatment for metastatic melanoma in routine clinical practice. However, response rates with single-agent DTIC are low. The objective of this ...
Author:Doriana Landi , Maria Albanese , Fabio Buttari ...
Data Source:[J].PLoS ONE(IF 3.73), 2017, Vol.12 (7)
Abstract:Flu-like syndrome (FLS) is a common adverse event experienced by patients with relapsing-remitting multiple sclerosis (RRMS) treated with interferon beta (IFNβ). FLS can lead to poor treatment adherence and early IFNβ discontinuation. The involvement of interleukin-6 (IL-6) ...
Author:Rosa Molfetta , Francesca Gasparrini , Giovanna Peruzzi ...
Data Source:[J].PLoS ONE(IF 3.73), 2017, Vol.4 (5)
Abstract:The best characterized role for ubiquitination of membrane receptors is to negatively regulate signaling by targeting receptors for lysosomal degradation. The high affinity receptor for IgE (FcepsilonRI) expressed on mast cells and basophils is rapidly ubiquitinated upon antigen ...
Author:Eli-Anne Skaug , Erik Madssen , Stian Thoresen Aspenes ...
Data Source:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (7)
Abstract:BACKGROUND: Several studies suggest that cardiovascular risk factors comprising the metabolic syndrome have larger effects on the development of cardiovascular disease in women than in men. A recent study in self-reported healthy subjects demonstrated a marked gender differe...
Author:Christopher M Penton , Jennifer M Thomas-Ahner , Eric K Johnson ...
Data Source:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (1)
Abstract:Muscle side population (SP) cells are rare multipotent stem cells that can participate in myogenesis and muscle regeneration upon transplantation. While they have been primarily studied for the development of cell-based therapies for Duchenne muscular dystrophy, little is kn...
Author:Barbara Lorber , Daniel J Chew , Stefanie M Hauck ...
Data Source:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (3)
Abstract:Axon regeneration in the adult central nervous system (CNS) is limited by several factors including a lack of neurotrophic support. Recent studies have shown that glia from the adult rat CNS, specifically retinal astrocytes and Müller glia, can promote regeneration of retina...
Author:Sandeep Gupta , Shunan Li , Md Joynal Abedin ...
Data Source:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (11)
Abstract:Acute kidney injury (AKI) has grave short- and long-term consequences. Often the onset of AKI is predictable, such as following surgery that compromises blood flow to the kidney. Even in such situations, present therapies cannot prevent AKI. As apoptosis is a major form of cell d...
Author:Hung-Wen Kao , Kwo-Whei Lee , Chen-Ling Kuo ...
Data Source:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (7)
Abstract:Interleukin-6 (IL-6), a proinflammatory cytokine, was found to surge in the cerebral spinal fluid after aneurysmal subarachnoid hemorrhage (SAH). We hypothesized that the plasma level of IL-6 could be an independent biomarker in predicting clinical outcome of patients with r...
Author:Wei-Wei Tuo , Di Wang , Wen-Jing Liang ...
Data Source:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (8)
Abstract:AIMS: Numerous studies have suggested that transfusion of red blood cells (RBCs) stored over a long period of time may induce harmful effects due to storage-induced lesions. However, the underlying mechanisms responsible for this damage have not been identified. Furthermore,...
Author:Declan J McKenna , Bernadette A Doherty , C Stephen Downes ...
Data Source:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (11)
Abstract:The alkaline single cell gel electrophoresis (comet) assay can be combined with fluorescent in situ hybridisation (FISH) methodology in order to investigate the localisation of specific gene domains within an individual cell. The number and position of the fluorescent signal...

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